TENG TO SPECIAL TREATMENT FOR AMNESIA SERIES

Senile dementia, also called Alzheimer's disease (AD), is a series of chronic progressive mental deteriorations occurring during or before the senile period characterized by progressive dementia as a result of brain dysfunction syndrome.1Ī large-scale clinical epidemiological survey showed that the prevalence of AD in people aged >65 was 4%-5%. Key words: Alzheimer disease Sodium-potassium-exchanging ATPase Learning and memory ability Yizhitongxuan decoction Then, the rats were sacrificed to collect The Morris water maze was used to examine the learning and memory abilities of rats in each group by place navigation and spatial probe tests.

METHODS: Ninety male Wistar rats (age >10 months) were selected and injected with Ap 25-35 into their hippocampi to establish model animals, which were randomly divided into six groups including a sham-operated group (blank group), a model group, a donepezil HCL group (Western Medicine group), and a high/general/dilute concentrations of Yizhitongxuan decoction groups (TCM inn group).

OBJECTIVE: To study the effects of Yizhitongxuan decoction on learning and memory abilities, Gaq/ 11 expression and Na+-K+-ATP enzyme activity in rat models of Alzheimer's disease (AD) caused by injecting Ap 25-35 into the hippocampus.

RESULTS: Yizhitongxuan decoction improved model rats' learning and memory abilities, and increased the expression of Gaq/11 in the hippocampus and the level of Na+-K+-ATP enzyme activity in brain tissue.ĬONCLUSION: Yizhitongxuan decoction could improve model rats' learning and memory abilities, and had a regulating effect on the expression of Gaq/11 and Na+-K+-ATP enzyme activity. The hippocampi for biochemical tests, using western blotting to detect the expression of Gaq/11 and an ultramicro Na+-K+-ATP enzyme kit to measure Na+-K+-ATP enzyme activity. Jing Teng, Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China. Jing Teng, Zhexue Xu, Jingmin Li, Department of Internal Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250011, China Jing Zhang, Department of Medical English, Shandong University ofTraditional Chinese Medicine, Jinan 250011, China Supported by the Project of Science and Technology in Shandong Universities of Shandong Provincial Education Department (No. Jing Teng, Zhexue Xu, Jing Zhang, Jingmin Li All rights reserved.Įffect of Yizhitongxuan decoction on learning and memory ability, Gaq/11 expression and Na-K-ATP enzyme activity in rat models of Alzheimer's Disease Yizhitongxuan decoction could improve model rats' learning and memory abilities, and had a regulating effect on the expression of Gαq/11 and Na+−K+−ATP enzyme activity. Yizhitongxuan decoction improved model rats' learning and memory abilities, and increased the expression of Gαq/11 in the hippocampus and the level of Na+−K+−ATP enzyme activity in brain tissue. Then, the rats were sacrificed to collect the hippocampi for biochemical tests, using western blotting to detect the expression of Gαq/11 and an ultramicro Na +−K+−ATP enzyme kit to measure Na+−K+−ATP enzyme activity. Ninety male Wistar rats (age ≤10 months) were selected and injected with Aβ25-35 into their hippocampi to establish model animals, which were randomly divided into six groups including a sham-operated group (blank group), a model group, a donepezil HCL group (Western Medicine group), and a high/general/dilute concentrations of Yizhitongxuan decoction groups (TCM I II III group). To study the effects of Yizhitongxuan decoction on learning and memory abilities, Gαq/11 expression and Na+−K+−ATP enzyme activity in rat models of Alzheimer's disease (AD) caused by injecting Aβ25-35 into the hippocampus. Abstract of research paper on Clinical medicine, author of scientific article - Jing Teng, Zhexue Xu, Jing Zhang, Jingmin Li

Teng to special treatment for amnesia